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ORIGINAL ARTICLE
Year : 2009  |  Volume : 17  |  Issue : 1  |  Page : 39-43

Comparision of different doses of Rocuronium Bromide in Burn Patients


Department of Anesthesiology, B.J. Medical College, Civil Hospital, Ahmedabad - 380016, Gujarat, India

Correspondence Address:
Bhavana Raval
4, Shayona Prasad Bungalow, Shayona city, R.C. Technical Road, Ghatlodiya, Ahmedabad - 380061, Gujarat
India
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Source of Support: None, Conflict of Interest: None


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Burn patients are usually resistant to the neuromuscular effects of nondepolarising muscle relaxants mostly because of receptor changes. The magnitude of the resistance is related to burn size and time after burn. Rocuronium 0.9mg/kg & 1.2mg/kg was used as the neuromuscular blocking drugs in burn as well as in non burn patients. Eighty patients were divided in to four groups. Forty burned patients ASA grade II & III aged 18 to 50 years, weighted 40 to 66 Kg burn area, was > 25% and < 40% with > 25 and < 60 days after burn injury were divided in to BO (0.9mg/kg Rocuronium) and B1 (1.2mg/kg Rocuronium). Another 40 non burn patients were divided in to NO (0.9mg/kg Rocuronium) and N1 (1.2mg/kg Rocuronium), as controlled group. After premedication with Inj. Glycopyrrolate 0.004mg/kg, inj. Midazolam 0.01mg/kg and inj. Fentanyl 1ug/kg intravenously. Anaesthesia was induced with inj. Propofol 2mg/kg IV. Rocuronium was given according to dosage. Neuromuscular block was monitored by using train of four stimulation. Onset time was prolonged in burn patients, 123 ± 9.97 seconds (0.9mg/kg) and, 85.2 ± 15.08 seconds (1.2mg/kg ), in compare with 82.3 ± 16.3 (0.9mg/kg) and 54.25 ± 9.79 seconds (1.2mg/kg) in non burn patients. Time to intubations was also prolonged in burn patients, 152.85 ± 25.27 seconds (0.9mg/kg) and 108.7 ± 13.01 seconds (1.2 mg/kg). Intubating conditions were graded on a three point scale as excellent, good, or poor. Recovery was observed as a time to reappearance of T1, 10%, 25%and 75% duration, Recovery index and TOF > 0.8 ratio and it was significantly shorter in burn patients as compared to non burn patients. This study shows that a 1.2mg/kg dose of Rocuronium provides good intubating conditions, faster onset time and recovery in compared with a dose of 0.9mg/kg.


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