| ORIGINAL ARTICLE |
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| Year : 2021 | Volume
: 29
| Issue : 1 | Page : 47-51 |
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Comparison of efficacy of intralesional triamcinolone acetonide at 2-, 4-, and 6-week intervals in hypertrophic scars and keloids
Vaishali Srivastava1, Shardendu Sharma2, Deepak Rathore3
1 Department of Burns and Plastic Surgery, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India
2 Department of Burns and Plastic Surgery, VMMC and Safdarjung Hospital, New Delhi, India
3 Department of Burns and Plastic Surgery, Max Hospital, New Delhi, India
Correspondence Address:
Dr. Vaishali Srivastava
E-106, Nicklaus Drive, Paramount Golfforeste, Greater Noida - 201 311, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0971-653X.206400
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Context: Keloids and hypertrophic scars are a cause of severe impairment of quality of life. Intralesional triamcinolone acetonide has been used at different intervals at various centers.
Aim: This study was aimed to compare the efficacy of intralesional triamcinolone acetonide at 2-, 4-, and 6-week intervals in hypertrophic scars and keloids.
Settings and Design: This study was conducted in the plastic surgery outpatient department of a tertiary care hospital. This is an interventional prospective study, randomization was done using a computer-generated sequence.
Materials and Methods: In this study conducted from October 2015 to January 2017, administration of triamcinolone acetonide 40 mg/ml at 2-weekly, 4-weekly, and 6-weekly intervals was done in case of hypertrophic scars and keloids for up to 8 doses or till Vancouver Scar (VCS) scale of 4 was achieved. VCS, pain, and itching were noted and compared.
Statistical Analysis: VCS scale was used for comparison using analysis of variance test. The visual analog scale was compared using an unpaired t-test. Qualitative data were compared using the Chi-square test/Fischer's exact test. P < 0.05 was considered statistically significant.
Results: The 2-weekly regimen was found to show better results in terms of pain and scar improvement. It also required a lesser number of doses to produce the same effect. The response to itching was comparable in 2- and 4-weekly groups and was better than 6-weekly group. Minimal complications were noted in the three groups.
Conclusion: Two-weekly regimen of triamcinolone acetonide is recommended for intralesional use in hypertrophic scars and keloids.
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